News — genomic sequencing

Probiotics are often marketed as harmless health boosters, capable of improving digestion, supporting immunity, and balancing the gut microbiome. But as their use increases in supplements, foods, and even clinical therapies, so do the questions surrounding their safety. One of the most powerful tools in answering these questions is genomic sequencing—a method that can reveal the full DNA blueprint of a probiotic strain.

Through whole-genome sequencing, scientists can screen for potential virulence factors and antibiotic resistance genes that might otherwise go unnoticed in traditional lab tests. While many probiotic strains are generally regarded as safe (GRAS), not all are created equal. Some carry genes that could transfer undesirable traits to other bacteria in the gut, leading to unintended consequences. In this article, we’ll explore how genomic sequencing ensures probiotic safety, what researchers are looking for, and why it’s critical in the era of precision health.