News — chronic migraine

For those struggling with chronic migraines, unpredictable digestive distress, or mysterious flushing, the culprit may not be an allergy, but a simple enzyme deficiency. This is the **DAO-Histamine Pathway**—a critical balance between the histamine we consume (and produce) and the **Diamine Oxidase (DAO)** enzyme our small intestine creates to break it down.

When DAO levels drop due to genetics, gut damage, or certain medications, dietary histamine floods the bloodstream, contributing to neuroinflammation, vascular headaches, and systemic sensitivity. This article dives deep into the science of histamine intolerance, its central role in the gut-brain axis, and practical strategies—from dietary changes to targeted supplementation—to restore this essential balance and find relief.