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What is Centrophenoxine?



Centrophenoxine, also named Lucidril and Meclofenoxate, is one of the most well-known and researched nootropics (or "smart" medications).

This medicine, which was first created in 1959, has been examined for its ability to aid people with age-related brain illnesses, including Alzheimer's and dementia. Healthy people utilize it to boost memory and cognitive function as well as overall brain health.

Composition of Centrophenoxine:

Let's talk about the composition of centrophenoxine. So basically, it is a composition of two chemicals listed below:

Dimethyl-aminoethanol (DMAE) is a naturally occurring substance found in some foods (fish, seafood) and small amounts in the brain. It contains choline and is thought to have brain-stimulating properties.

A synthetic equivalent of plant growth hormones known as "auxins" is parachlor phenoxyacetic acid (pCPA).

According to the Research:

Centrophenoxine is a cholinergic molecule that contains DMAE (Dimethylaminoethanol) and serves as a better absorbed DMAE transporter in the brain. Lucidril is the brand name, and it is widely available over the counter or online.

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When taken for a short period (high dosages for a month), it can reverse some of the indications of aging (especially waste product buildup in the brain). When taken constantly at a lower level, it can work as a general neural enhancer and protector.

Centrophenoxine from Safety Point of view:

Most research has found that centrophenoxine has modest adverse effects, such as nausea, headache, dizziness, gastrointestinal difficulties, and mild stimulant effects. 

DMAE, the active component of centrophenoxine, has raised safety concerns in a few studies. Three significant adverse events occurred in a clinical study of DMAE in 242 Alzheimer's patients: heart failure leading to death, cardiac arrest, and seizure. The researchers couldn't rule out the likelihood that DMAE caused the episodes. 

Preclinical investigations have shown that DMAE causes neural tube abnormalities; hence, women of childbearing age should avoid it.

Potential Benefits of Centrophenoxine:

Here are some of the Potential Benefits of centrophenoxine you need to know.

  • Centrophenoxine has insufficient and inconclusive clinical evidence. The most comprehensive and well-conducted study was a 74-person double-blind, randomized control trial that looked at the effects of a 9-month centrophenoxine therapy on cognitive skills.
  • After treatment, the centrophenoxine group outperformed the placebo group on a memory test called delayed free recall, which was linked to the consolidation of new knowledge into long-term memory. On the other five memory tests, however, there were no treatment effects.
  • Centrophenoxine has been proven in preclinical trials to increase learning and memory in elderly animals and those with memory impairment or stroke. Centrophenoxine's capacity to reduce inflammation, oxidative stress, and amounts of damaged proteins and lipids in the brain might explain these advantages. However, these prospective advantages have yet to be shown in people.

There are always researches happening on each compound for decades. Likewise, there are some pieces of evidence and researches put forward related to centrophenoxine. But this evidence is Lacking and insufficient. These shreds of evidence are listed below:

The insufficient evidence:

Centrophenoxine has effects on Learning and Memory:

Centrophenoxine, a so-called "nootropic" or "cognitive-enhancing" compound, has been claimed to improve specific cognitive processes in users, such as memory consolidation. What, on the other hand, does science have to say about this?

Although some studies have found centrophenoxine advantageous in some populations of older people, no reliable scientific evidence supports its usage as a nootropic in young adults.

Centrophenoxine, for example, was found to aid in the development of long-term memory and enhanced alertness in 60 healthy – but aged – human individuals in one research 

Centrophenoxine has also been shown to improve cognition in 50 senior dementia patients.

The Lacking Evidence:

Centrophenoxine maybe Neuroprotective:

One of the most widely held beliefs regarding centrophenoxine is that it can protect the brain and its cells from stress and harm or that it is "neuro-protective."

Although proper human studies are currently lacking, a few lines of animal research have published preliminary data that give some insufficient evidence for this impact.

Centrophenoxine, for example, has been shown in animal tests to protect brain cells from oxidative damage caused by toxin exposure or stroke. 

Centrophenoxine was shown to minimize free-radical damage and may have averted certain cognitive losses in rats with various forms of brain injury.

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